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For example, a functional score change in a rodent injury model may reflect altered edema, preserved microvascular flow, changed inflammatory response, neurotransmitter modulation, or general systemic stabilization after experimental injury

Treatment protocols typically involve gradual dose introduction and regular assessment of tolerability to minimize adverse effects

However, HE staining showed slight folding, shrinking and delamination of the basement membrane of seminiferous tubules in the rat testicular tissue, an increasing amount of sperm, insignificant damage to spermatogenesis, a lack of mature spermatogenic cells, a slightly disordered and sparse cell arrangement with 35 layers and visible cell polarity in groups C and D