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L-citrulline serves as a reservoir of arginine in the body and is directly converted to arginine, thus indirectly boosting nitric oxide levels

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ICERs value assessment framework considers the health benefits of a treatment (in QALYs and other metrics) relative to its price, typically using $100,000150,000 per QALY as benchmark thresholds (with exploration up to $200,000/QALY for severe cases) ( [8] ) ( [9] )