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Mechanistically, Lebeau et al

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Clinical trials (using the Wegovy formulation) have shown that when combined with lifestyle changes, non-diabetic participants lost about 12-13 percentage points more body weight compared to those taking a placebo over 68 weeks

Nevertheless, a critical caveat is that many findings on iTreg stability come from in vitro systems, and their physiological relevance, particularly in human disease, requires further validation