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[ 1-3] While dietary and lifestyle changes can be effective in promoting ideal body weight, the reality is that in obesity, the use of diet and lifestyle alone produces poor results as only about 5-15% of these people will achieve a 20% loss in body weight and most regain that weight within a year of losing it

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One of the hypothesized reasons is the existence of an extra copy of amyloid precursor protein (APP) gene located on chromosome 21

GLP-1 therapies and hormone replacement work through different but complementary pathways, and combining them can produce significantly better results than either approach alone