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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells

Think of it like the difference between watering a plant directly at the roots versus hoping some rain might eventually trickle down to it

Furthermore, using GHK-Cu peptide nasal spray has been found to support tissue remodelling, which has beneficial effects on the healing of ischemic open wounds, acne scars, and soft tissue repair

Is there a difference between GHK and GHK-Cu