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The mechanisms by which the Trx system regulates autophagy in various diseases are summarized in Table I, highlighting its molecular interactions and bidirectional regulatory effects on autophagy

GSH levels decrease with age and possible development of AD

Any change of therapy belongs in a doctors hands in every case, not done on your own

Therefore, in patients where the fasting glucose is a more dominant feature of their hyperglycemia, metformin may be more appropriate, while GLP-1RAs could be better suited for those with postprandial hyperglycemia