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2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

Although initially intended for type 2 diabetes, tirzepatide trials have evidenced considerable weight loss impact because the drug triggers both GLP-1 and GIP receptors that reduce hunger and control blood sugar

Siddiqui, A.H