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Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective
Some researchers have suggested that these promising results warrant further research to study the compounds potential benefits for metabolic conditions like type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD) [5]
Allosteric inhibitors : By binding to allosteric sites rather than active sites, these drugs achieve high target selectivity
Notably, LASSS displayed additional functions to promote receptor binding-affinity and nitration resistance of HGF in a dose-dependent manner, that is high-dose LASSS in excess of a 1:4000 molar ratio to HGF, as revealed by biochemical assays after wash-out of un-reacted free LASSS (Figure 2a-d)
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