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Abstract Background and Objectives Cagrilintide is a long-acting amylin agonist under development as monotherapy for weight management and as a fixed-dose combination with the glucagon-like peptide-1 receptor agonist semaglutide (CagriSema) for weight management and treatment of type 2 diabetes

Peptides such as semaglutide and tirzepatide work by mimicking naturally occurring hormones that regulate appetite, blood sugar, and insulin sensitivity