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Although growing evidence highlights the impact of choline metabolism on macrophages and microglia, there is a knowledge gap regarding its effects on other tissue-resident immune sentinels, such as Kupffer and Langerhans cells

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In addition, the use of GLP-1 RAs has significantly reduced the risk of mortality, MACE, and MAKE in patients requiring metformin or insulin therapy, suggesting the cost-effectiveness of GLP-1 RAs in these high-risk patients 41