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Disruptions in circadian rhythm have also been widely reported in patients with bipolar disorder, and sleep deprivation is a known trigger, particularly of manic and hypomanic episodes [73,74,75,76]

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2 Data suggest that plasma and hepatic GSH also are decreased in patients with acute viral hepatitis, or chronic liver injury from a variety of causes such as chronic hepatitis, nonalcoholic liver cirrhosis, and alcoholic liver disease