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Mice with reduced adipose NNMT, when fed high-fat diets, gained less weight than control mice a striking adipose-specific effect

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Research involving these pathways remains ongoing, particularly within broader investigations involving cellular-response mechanisms, oxidative-stress regulation, and tissue-maintenance research

Our experience suggests that while a systemic dose will eventually reach the ankle, a localized dose may create a much higher concentration gradient in the target tissue for a more potent and immediate effect