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Anti-angiogenic mechanism Natural products exert their anti-angiogenic effect through the inhibition of key molecular targets such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-alpha (HIF-1), as well as direct effect on endothelial cells, such as human umbilical vein endothelial cells (HUVECs), inhibiting their proliferation and ability to form capillary-like structures

Kato S, Fukui K, Kirigaya H, Gyotoku D, Iinuma N, Kusakawa Y, Iguchi K, Nakachi T, Iwasawa T, Kimura K (2016) Inhibition of DPP-4 by alogliptin improves coronary flow reserve and left ventricular systolic function evaluated by phase contrast cine magnetic resonance imaging in patients with type 2 diabetes and coronary artery disease

Table 1: Subtypes of Psoriasis (NIH 2013

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