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Description

Mouse islets were transduced 24 hours prior to imaging with an adenoviral SNAP/FLAG-hGLP-1R vector (custom made by VectorBuilder) at a MOI of 1 and subsequently labelled for 10 minutes at 37 C with SNAP-Surface Alexa Fluor 647 before 5-minute stimulation with indicated agonists and imaging of whole islets in the same microscope as above

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All administration must follow trial team instructions, and used sharps must be disposed of in an approved sharps container

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the same class of adverse events seen with GLP-1 monotherapy

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