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Overall, these limitations might encourage the search of different approaches, which might combine a more favorable compliance and safety, with acceptable efficacy and with more affordable treatment regimens, and might be therefore particularly suited in a minority of patients experiencing one or more hindrances to PDE5i treatment

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Laruelle, M., Blood brain barrier permeability of [11C]loperamide in humans under normal and impaired P-glycoprotein function[symposium abstract]