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After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin
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Further evidence that the two proteins interact is provided by size-exclusion chromatography multi-angle light scattering measurements, which show dissociation of the Ab DGC dimer into monomers upon addition of the photocobilin domain ( Ab Pcob)
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