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Based on the here-presented biochemical, structural and computational evidence, we propose that arGSTs utilize a GSH-dependent Brnsted base mechanism for conversion of the semi-stable LDOX product flavan-3,3,4-triol ( 4 ) or flavan-3-on-4-ol ( 7 ) into flav-2-en-3,4-diol ( 8 -B4), the 4-hydration species of cyanidin ( 8 ) (Extended Data Fig

While all GLP-1 drugs influence appetite and metabolism, only some (like semaglutide and tirzepatide) are FDA-approved specifically for weight management

Severe hypoglycaemia can cause confusion, loss of consciousness, seizures, and cardiovascular events

GLP-1 drugs like Ozempic act directly on hormone pathways: they mimic the glucagon-like peptide-1 hormone, which slows stomach emptying, reduces appetite, and boosts insulin secretion from the pancreas