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doi: 10.1006/cimm.1995.1183 25 GrimsteinCChoiYKWasserfallCHSatohMAtkinsonMABrantlyMLet al

This 48-week, phase 2, dose-ranging trial enrolled 338 adults with obesity (BMI 30) but without diabetes, randomising participants to placebo or one of four retatrutide doses: 1mg, 4mg, 8mg, or 12mg administered subcutaneously once weekly

Everything else marketed for brain aging, from NAD+ precursors and senolytics to metformin, rapamycin, and CoQ10, has either failed in human trials or has not been tested in the brain at all, which is why those belong in the promotion section below rather than here

Johnson FD, Ferrarone J, Liu A, Brandstdter C, Munuganti R, Farnsworth DA, et al