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NAD + has an essential role as a source of ADP-ribose for three main classes of enzymes, each releasing nicotinamide as a byproduct: 1) mono- and poly-ADP-ribosyltransferases (ARTs, formerly PARPs) utilize ADP-ribose to modify proteins post-translationally and get activated during DNA repair processes 8

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The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor gamma coactivator 1alpha gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial

Specifically, heart attack rate was 44% lower, stroke rate was 63% lower, rate of cardiac death was 45% lower, and rate of peripheral artery disease requiring amputation was 43% lower with omega-3 fatty acids than placebo (corn oil)