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For context, semaglutide and tirzepatide do not produce dysesthesia at clinically significant rates, though a recent paper in PMC examined allodynia and dysesthesia reports across GLP-1 medications more broadly

Interactions between gut microbiota and immunomodulatory cells in rheumatoid arthritis

Its distinctive characteristic is a structural modification involving the attachment of a C18 fatty diacid chain (acylation) via a spacer to the lysine at position 26