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[] PCa, in its early stages, may present symptoms such as excessive urination, frequent nighttime urination (nocturia), difficulty in initiating and maintaining regular urination, blood in the urine (hematuria), and painful urination (dysuria)

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Consequently, suppressing the MVA pathway can downregulate GPX4 activity and induce ferroptosis (Warner et al., 2000)

We also thank the University of Michigan Medical School Central Biorepository (RRID:SCR_026845) for providing biospecimen storage, management, and distribution services in support of the research reported in this study