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Rather, the labels downplay the severity of gastroparesis symptoms, and omit that they can be a feature of potentially life-threatening digestive impairment. Plaintiffs also noted that defendants failed to warn users that they need to stay on the drugs for the rest of their lives, or else they are likely to gain the weight back

Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023

2024 doi: 10.1177/15598276241280207

and Severe Obesity Prevalence in Adults: United States, August 2021-August 2023 Key findings Data from the National Health and Nutrition Examination Survey [Internet]