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Semaglutide works on the GLP-1 pathway

The fact that prolong Hp infection and accompanying atrophic gastritis results in the decrease in the number of the Gr cells that is paralleled by the decrease in plasma levels of pepsinogen I, which is considered as biomarker of the integrity of the oxyntic mucosa, suggests that Hp may indeed interfere directly with the Gr-cells and ghrelin release but this requires further studies (59)

Data suggests the peptide modulates the release of adrenocorticotropic hormone (ACTH) and limits baseline cortisol levels during simulated stress events inside cell cultures