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Moreover the lack of TNFR2 (selective ablation of TNFR2) in astrocytes resulted in changed expression of key proteins involved in hippocampal synaptic transmission and plasticity, increased hippocampal gliosis, impaired LTP, and deficits in learning and memory in males as compared to females [84]

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A meta-analysis of 37 RCTs found that testosterone therapy reduced total body fat by an average of 1.6 kg and increased lean mass by 1.6 kg

Face serums and creams: Clinical standard: 1-3% concentration Maximum typically used: 4% concentration Application: Once or twice daily Duration: Minimum 8-12 weeks for visible results Eye area products: Concentration: 1-2% (lower for sensitive periorbital skin) Application: Once daily, typically evening Amount: Pea-sized for both eyes Scalp solutions for hair: Concentration: 0.5% solution common Application: 1-2ml to affected areas once or twice daily Duration: 3-6 months minimum for meaningful changes Higher concentrations do not always mean better results with topicals