Recently, cefiderocol was used to successfully treat ventilator-associated pneumonia caused by Stenotrophomonas maltophilia in a preterm neonate (Koirala et al., 2023)
Early data suggests that some risks, particularly diabetic retinopathy worsening, appear highest in the first three to six months of treatment
These are preclinical, cell-based observations, and experimental outcomes depend on intracellular NAD+/NADH ratios, compartmentalisation and the metabolic state of the model system
In some embodiments, formulations or compositions described herein provide a constant, sustained, extended, delayed or pulsatile rate of release of an active agent into the inner ear environment and thus avoid any variability in drug exposure in treatment of otic disorders