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Phentermine-topiramate (Qsymia) Topiramate, long used for seizure disorders and chronic migraine headache, was approved for obesity treatment in an extended-release combination with phentermine in 2012

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Certain natural plant compounds have been shown to support GLP-1 production in lab and animal studies: Flavonoids like (-)-epicatechin (found in dark chocolate) and anthocyanins (from berries and purple veggies) have been shown to increase GLP-1 and improve metabolism via the PKA signaling pathway (Cremonini et al., 2021)