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In obese individuals, the expression and activity of aromatase in the adipose tissue are enhanced, thereby promoting the synthesis of peripheral estrogen and leading to elevated systemic estrogen levels (66)

Plan for long-term treatment or have a comprehensive maintenance strategy in place before stopping

(AVMA), A

The magnitude of weight loss in particular, as observed in clinical trials and as popularized across social media, may vary in the real-world and among patients with different backgrounds, clinical profiles and history as compared to protocolized weight loss clinical trials