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Still, its unique receptor profile means extrapolation of safety data from other agents should be done with caution (Table 2)

Jardiance also has more approved indications as a treatment for heart failure and for CKD

While the vast majority of GLP-1 axons in the spinal cord evidently originates from lower brainstem neurons 9,20 , PPG-promoter driven transgene expression suggested that GLP-1 may be produced locally by a small population of neurons 20