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demonstrated that in AR mice treated with D-pinitol symptoms of improvement were seen due to Th1/Th2 response balancing such as reducing the IgE, IgG1, IL-4, IL-5, IL-13, LTC-4 and increasing the IFN- levels in nasal lavage fluid also reduce the GATA-3, STAT-6, SOCS1, TLR4, and MyD88 expression and increase the T-bet expression in the spleen tissue (You et al., 2021)
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