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Retatrutide produced 24.2% average weight loss at 48 weeks through triple receptor agonism (GIP/GLP-1/Glucagon), while Survodutide achieved 14.9-18.7% weight loss at 46 weeks through dual receptor agonism (GLP-1/Glucagon)

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However, this risk is still rarefewer than 2% of patients develop symptomatic gallstonesand must be weighed against tirzepatide's superior metabolic benefits