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Description

Lo primero que se podra decir en relacin con la combinacin de iSGLT2 (accin independiente de insulina) ms AGLP1 (accin dependiente de insulina) es que tiene un soporte en los tiempos de sus mecanismos de accin, debido a que los iSGLT2 proporcionan sus efectos protectores cardiovasculares a travs de mecanismos ms hemodinmicos a corto plazo: 3-6 meses EMPA REG , 42 mientras que los AGLP1 los proporcionan tericamente ms a travs de accin antiaterognica y antiinflamatoria a largo plazo: 12 meses LEADER 43 y SUSTAIN, 44 lo que hace que esta combinacin produzca proteccin cardiovascular a corto y largo plazos

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A rapidly acting glutamatergic ARCPVH satiety circuit postsynaptically regulated by -MSH [published correction appears in nat neurosci

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