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Finally, a fourth lesson is that the development has indeed been fruitful not for only the generation of new agents to be introduced to the patients but also for the scientific field, since novel scientific discoveries have been made throughout these years in this development

Its safety, efficacy, and pharmacological effects in humans or animals have not been established

Conclusions BBB breakdown significantly impacts the development and progression of neurodegenerative diseases, and unraveling the cellular and molecular mechanisms underlying BBB dysfunction is vital to elucidate how neural computations are sustained under pathological conditions and to devise therapeutic approaches