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Semaglutide Semaglutide has been developed based on the vast body of research behind the development of liraglutide ( N -[8-(2-hydroxybenzoyl) aminocaprylate] or SNAC), which, when co-administered with semaglutide, was demonstrated to give therapeutic levels of the latter ( Both the subcutaneous and oral formulations of semaglutide have undergone extensive phase 3 clinical testing ( Table 1 )

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It is a powerful tool in treating obesity and type 2 diabetes, especially when combined with healthy habits and regular medical care

Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]