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how do you wean off glp 1 Weaning GLP-1 Medications: Complete Tapering Guide How to Safely Stop Wegovy:

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Additionally, GLP-1 RAs can modulate appetite-regulating centers in the hypothalamus, such as directly activating POMC neurons [63] or inhibiting AgRP neurons by acting on GLP-1R-expressing neurons in the dorsomedial hypothalamus [61,63]

How these next-generation treatments will be formulated for oral delivery, and what dosing frequencies they will require, remains an active area of research