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If your Current Weight is: Your new weight could be: Average study participant lost 15% *In the STEP 5 trial, participants for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes, patients taking semaglutide (typically in doses of 2.4 mg once weekly) for weight management lost an average of about 15% of their body weight over 68 weeks

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However, tirzepatide possesses biased agonist properties toward the GLP-1 receptor [75], suggesting that it may sustainably activate the GLP-1 receptor in vivo

10.1124/pr.112.005850 85 ClarkeG.GrenhamS.ScullyP.FitzgeraldP.MoloneyR