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(Source) When this enzyme is present in great concentration within fat cells and is highly expressed, obesity is inevitable: In the study by Kannt and colleagues, NNMT expression is increased ~2-fold in subcutaneous and omental adipose tissue of type 2 diabetic subjects (men and women), compared to healthy controls Importantly, interventions that increase insulin sensitivity, such as exercise and bariatric surgery, also decreased expression of NNMT in adipose tissue For this reason alone, scientists have been interested in every possible method for inhibiting NNMT expression: We report that NNMT expression is increased in [white adipose tissue (WAT)] and liver of obese and diabetic mice

For a physician, there is no bigger reward than changing peoples lives for the better and the Breakthrough Prize reflects that. Druckers prize received widespread media attention, with the Canadian Press noting that his breakthroughs have changed the lives of millions of people around the world. GLP-1 medicines burst into public consciousness in recent years following evidence of their myriad health benefits

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J Cell Biol 178 (1): 93105