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How GLP-1 Drugs Target Both at Once GLP-1 receptor agonists were designed for metabolic purposes: regulating blood sugar, slowing gastric emptying, and reducing appetite

MASH improvement (no fibrosis worsening) at 2.4mg: 47% MASH improvement (no fibrosis worsening) at 4.8mg: 62% MASH improvement (no fibrosis worsening) at 6.0mg: 43% Placebo MASH improvement: 14% Liver fat reduction of 30%+ at 4.8mg: 67% Fibrosis improvement by 1+ stage: 34-36% These results led to FDA Breakthrough Therapy designation, which accelerates the development and review process for drugs addressing serious conditions