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When theres sub-optimal glucose and highly active neurons have limited access to energy, they dysfunction and ultimately die on a chronic basis. The most active neurons are in regions of learning and memory, Fillit said, making them more susceptible to glucose deprivation and, ultimately, neurodegeneration

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Future research should employ advanced methodologies such as systems biology, single-cell transcriptomics, spatial omics, and high-resolution imaging to map the regulatory landscape of tophus formation with greater precision