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however, there was severe cell death when both cystine and GSH were depleted (Fig

Safety was also assessed

The patients neurologic examination was normal outside of symptomatic flares, and she reported no sweating abnormalities

These critical mediators modulate immune function and inflammatory responses through genomic and non-genomic regulation of intracellular metabolic pathways, including glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation