Hormones also control growth, mood, and other important functions
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In a phase 2b dose-ranging trial [FRONTIER 1 (NCT05223868)], adult participants with moderate-to-severe plaque psoriasis ( n = 255) were randomized to receive five different doses of oral icotrokinra (25 mg daily, 25 mg twice daily, 50 mg daily, 100 mg daily, or 100 mg twice daily) or placebo for 16 weeks [86]
Moving forward, Felson wrote, "it will be important to obtain data on whether semaglutide is similarly effective in persons with osteoarthritis without obesity, as well as better data on whether GLP-1 receptor agonists prevent progressive structural deterioration of the joint in osteoarthritis." This double-blind STEP-9 study was conducted at 61 sites across 11 countries starting in October 2021
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