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Many chronic conditions persist not because the original injury was severe, but because the inflammatory response never properly resolved

Morphologically, the most important morphological changes of ferroptosis are mitochondria, including mitochondrial contraction, electron-dense mass formation under ultrastructure, reduction or disappearance of mitochondrial cristae, changes in membrane potential, and rupture of mitochondria outer membrane (Vanden Berghe et al., 2014)

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This may produce higher average but lower real-world applicability