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Overall, KAR desensitization appears to work as a multistep process, with a shallow desensitized state characterized by two-fold symmetry of the LBD layer, consecutively progressing through an asymmetric conformation to a deeply desensitized state with the four-fold symmetrical LBD layer and completely dissociated LBD dimers (Figures 8AC)

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More recently, they compared therapeutic efficacy of Wuzhi tablet to N-acetylcysteine, which is the main antidote for APAP toxicity (Fan et al., 2015)

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