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Cellular senescence in ovarian somatic cells, including GCs and stromal cells, may further exacerbate oxidative stress and inflammatory signaling within the follicular niche [80, 81, 82] Together, these interconnected mechanisms and hallmarks of aging suggest that reproductive aging shares common biological pathways with systemic aging, supporting the view that oocyte aging should be considered within a broader geroscience context

Although direct evidence specifically linking HDAC inhibitors to tinnitus mechanisms is limited, the broader principle is that agents capable of reversing detrimental epigenetic changes hold therapeutic potential for various brain disorders, including those with symptoms like tinnitus

Streamlined diagnostic pathways can reduce delays while maintaining diagnostic accuracy

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