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Specifically, C- Glud1 +/ mice exposed to mild stress, which was nearly inconsequential in C-Cre+ controls, exhibit deficits in spatial acquisition and reversal learning, alterations in prefrontal changes in glutamatergic and GABAergic gene expression, and long-lasting changes in miRNA expression

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Furthermore, a clear dose-response relationship was observed, wherein higher doses were associated with greater symptomatic relief [140]

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