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Medication review is essentialdose reduction or temporary discontinuation may be necessary if side effects are severe, and concurrent medications (particularly insulin or sulfonylureas) may require adjustment

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It not only provides the material and energetic basis for the unlimited proliferation of tumor cells, but also reshapes the tumor immune microenvironment (TIME) by regulating metabolite levels (including lactate, glutamate, serine, etc.) and mediating epigenetic modifications such as histone lactylation and methylation