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Additionally, phentermine's stimulant properties can interfere with semaglutide's ability to establish stable hormone signaling, reducing the GLP-1 medication's overall effectiveness

Nature 404(6778):661671 Lam CK, Chari M, Lam TK (2009) CNS regulation of glucose homeostasis

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Importantly, these effects could be recapitulated in cysteine desulfurase (NFS1) knockdown cells with impaired iron-sulfur cluster synthesis, indicating that phenotypes observed in SLC25A39/40 knockout cells are likely a consequence of an iron-sulfur cluster deficiency (Extended Data Fig