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But in contrast to GLP-1GIP, GLP-1GIPLani exhibitied similar effectiveness to Lani in promoting the expression of the PPAR target gene PDK4 in GLP-1R and GIPR-expressing HEK293T cells transfected to co-express PPAR, PPAR or PPAR (Fig

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doi: 10.3233/CBM-150484 131 KawaharaNKawaguchiRMaehanaTYamanakaSYamadaYKobayashiHet al

In parallel, amylin-based co-agonist strategies, exemplified by the long-acting amylin analogue cagrilintide and its combination with semaglutide, introduce an additional satiety-related signalling axis (110)