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This may be due to copper's ability to enhance the expression of metalloproteinases (MMPs).16 MMPs normally regulate the degradation of collagen, and a specific one, MMP-1, may be responsible for the initiation of collagen fragmentation.17 Supporting this, a 2024 study noted that elevated MMP-1 levels appear to contribute to aging skin and that higher MMP-1 levels in mice led to:18 The loss and fragmentation of dermal collagen fibrils Contracted fibroblast morphology Reduced collagen production Increased expression of pro-inflammatory mediators Additionally, a 2016 study found that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration, which the studys authors considered to be one of the reasons the peptide was able to increase collagen and elastin production.19 So, what this could ultimately mean is that using too much GHK-Cu (or other copper peptides) may in theory increase the skins MMP-1 concentration above the levels involved in healthy collagen production, taking it into the collagen fragmentation and breakdown territory seen in older skin with naturally higher MMP-1 levels

TIER 1 (40mg total) $370 total for 8-10 week supply Monthly cost breakdown: $148-$185 based on weekly dose Recommended if new to treatment or for those on 2-5mg/week TIER 2 (60mg total) $445 total for 8-10 week supply Monthly cost breakdown: $178-$220 based on weekly dose Recommended for those on 6-7mg/week TIER 3 (80mg total) $575 total for 8-10 week supply Monthly cost breakdown: $288-$292 based on weekly dose Recommended for those on 8-10mg/week TIER 4 (120mg total) $725 total for 8-10 week supply Monthly cost breakdown: $290-$363 based on weekly dose Recommended for those on 11mg/week and up Custom Semaglutide Injectables Custom-compounded Semaglutide injectables are expertly formulated by our partner pharmacies to support your personalized wellness and weight management goals

Particularly in lean individuals or those with pre-existing low body fat

Adjustments should always be made under medical guidance