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In some cases, activation is accomplished by snake Gla-containing enzymes that bind to the endothelium of human blood vessels and catalyze the conversion of procoagulant clotting factors into activated ones, leading to unwanted and potentially deadly clotting

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Among these, HBV is considered the most important due to its significant global health impact, including widespread chronic infection, high infectivity, and its role as a leading cause of liver disease and liver cancer ( Despite the availability of a safe and effective vaccine, HBV remains a leading cause of chronic liver disease worldwide