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Fresh tissue damage still has the cellular machinery for repair actively engaged, while chronic injuries may have entered a degenerative plateau

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Thus, phytochemical modulation of the L-arginine/NO/cGMP/K ATP pathway should be conceptualized as a dynamic, context-dependent interaction with multiple feedback and feedforward loops rather than a simple linear cascade

10.1016/j.clineuro.2016.07.011 Clin